In this retrospective cohort study that was performed at Tehran Heart Center, we enrolled all patients who underwent primary or elective PCI and completed their 5-year followup unless they developed events related to study end-points. Data were retrieved from the THC databank. Glomerular filtration rate (GFR) was calculated based on the Cockcroft-Gault equation for men and women, separately. Patients were then classified into three groups based on the level of GFR (GFR ≥ 60, GFR < 60 and ≥30 and GFR < 30 mL/ min) and the predictive effect of GFR on MACE was then analyzed.
A total of 632 cases (16.7%) occurred in patients with GFR > 60 while 224 cases (18.8%) and 35 events (43.7%) occurred in patients with 30 ≤ GFR < 60 and GFR < 30 mL/min, respectively. So, GFR < 30 mL/min was significant predictor for MACE (hazard ratio [HR] = 3.74, 95% CI: 2.64-5.28; P < 0.001). The prediction effect of GFR < 30 remained significant after adjustment for the confounding variables (HR = 3.43, 95% CI: 2.38-4.94; P < 0.001).
We concluded that GFR <30 mL/min was a strong predictor for 5-year MACE.