Based on a recent study published in New England Journal of Medicine, supplementation with vitamin D has no significant effect on the risk of cancer or cardiovascular disease.
In a a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 at a dose of 2000 IU per day and marine mega-3 fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or older and women 55 years of age or older in the United States. The study comprised of 25,871 participants, including 5106 black participants.
The study results showed that supplementation with vitamin D3 (at a dose of 2000 IU per day) did not lead to a significantly lower incidence of invasive cancer of any type or a composite of major cardiovascular events (myocardial infarction, stroke, and death from cardiovascular causes) than placebo. The intervention also did not lead to a lower incidence of total deaths from cancer or a lower incidence of breast, prostate, or colorectal cancer than placebo.
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