My latest paper: Predictive Value of NT-Pro BNP in the Detection of Coronary Artery Disease

Serum level of NT-Pro BNP alone and its combination with the results of MPI can significantly predict the presence of CAD and therefore, highlights the need for performing coronary angiography.

In our recent study paper, published in the Medical Journal of The Islamic Republic of Iran, we showed that the Serum level of NT-Pro BNP alone and its combination with the results of myocardial perfusion imaging can significantly predict the presence of CAD and therefore, highlights the need for performing coronary angiography.

In this cross-sectional study, stable angina patients with positive MPI who were assessed by coronary angiography in Imam Khomeini Hospital were enrolled. After the collection of demographic and clinical data, NT-ProBNP was measured in all patients on the day of coronary angiography, and its association with the presence of CAD, vessel score and Gensini score was tested.

Our results showed that NT-Pro BNP was significantly higher in the CAD-positive group (OR=1.01, 95% CI: 1.00-1.02; p=0.008) and could independently predict the presence of CAD at a cut-off point of 69.5, with a sensitivity of 55.6%, specificity of 82.5% and diagnostic accuracy of 61.7%. The Gensini score had a modest correlation with NT-Pro BNP (r=0.60, p<0.001). The combination of MPI result and NT-Pro BNP could predict the presence of CAD (OR=14.57, 95% CI: 4.28, 49.56; p<0.001).

We concluded that due to the invasive nature of the coronary angiography, use of NT-Pro BNP can assist the clinicians to decide more incisively about the need for performing coronary angiography in an individual patient.

Read the article here.

Share on telegram
Telegram
Share on linkedin
LinkedIn
Share on facebook
Facebook
Share on twitter
Twitter

Leave a Reply